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KMID : 0385920200310020152
Journal of the Korean Society of Emergency Medicine
2020 Volume.31 No. 2 p.152 ~ p.160
Does delta neutrophil index predict 30-day mortality in patients admitted to intensive care unit via emergency department?
Yoon Young-Tak

Kim Young-Sik
Ha Young-Rock
Shin Tae-Yong
Jung Ru-Bi
Lee Kyoo-Hyun
Yu Woo-Sung
Kim Dong-Hoon
Abstract
Objective: A retrospective study was performed to evaluate the usefulness of the delta neutrophil index as a prognostic factor for mortality in intensive care unit patients admitted via the emergency department.

Method: Patients, who presented to the emergency department and were admitted to the intensive care unit from January 2018 to August 2018, were reviewed retrospectively. The clinical features, inflammatory marker levels, such as C-reactive protein, lactate, simplified acute physiology score 3, length of stay, and in-hospital mortality were obtained from the medical records. Patients, who visited the emergency department because of trauma or suicidal attempts, arrived after out-hospital cardiac arrest, or were diagnosed with cerebrovascular disease, were excluded.

Results: Of the 310 patients included, 65 died during their admission, and 245 patients were discharged after treatment. The receiver operating characteristic curve showed that the delta neutrophil index (area under curve [AUC], 0.72), Creactive protein (AUC, 0.70), lactate (AUC, 0.64), and simplified acute physiology score 3 (AUC, 0.79) indicated a low predictive power for in-hospital mortality. Whole patients were divided into four subgroups (infectious diseases, cardiovascular diseases, gastrointestinal bleeding diseases, and others). The receiver operating curve of delta neutrophil index revealed infectious diseases (AUC, 0.65), in cardiovascular diseases (AUC, 0.70), and gastrointestinal bleeding diseases (AUC, 0.79).

Conclusion: The role of the delta neutrophil index for predicting the prognosis of in-hospital mortality showed equally low predictive power for critically ill patients with the C-reactive protein and lactate.
KEYWORD
Delta neutrophil index, Mortality rate, Emergency department, Intensive care unit
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